Oxaliplatin
Class:Cytostatic
Mechanism of action
Oxaliplatin inhibits
cell division by cross linking strands of DNA molecule.
Indications
Platinum coordination
coplex in combination with infusional 5-FU/LU is indicated for the treatment of
patients with metastatic carcinoma of the colon or rectum whose disease has
recurred or progressed during or within 6 months of completion of first line
therapy with the combination of bolus 5-FU/LV and irinotecan.
Contraindications
Hypersensitivity to
oxaliplatin or other platinum compound.
Side effects
Anaemia,neutropenia,fever,flushing,diarrhea,nausea,peripheral
neuropathy,vomiting.
Dosage
130mg/m2(range
85-135mg/m2) IV for one dose on day 1.30mg/m2/day by continuous IV infusion for
5 consecutive days(total dose per cycle 150mg/m2).
Brands
Inj.Oxalite
50,100mg,Inj.Oxitan.
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