Aspirin

Aspirin

Class:Non-Norcotic analgesic,anticoagulants/platelet aggregation

Mechanism of action

Inhibits prostaglandin synthesis,acts on the hypothalamus heat regulation center to reduce fever,blocks prostaglandin synthetase action which prevents formation of the platelet aggregation substance thromboxane A_2.

Pharmacokinetics

Duration:4—6 hours.Absorption:from stomach and small intestine.Distribution:readily distributes into most body fluids and tissues.Metabolism:hydrolyzed to salicylate(active) by esterases in the GI mucosa,red blood cells,synovial fluid and blood;Metabolism of salicylate occurs primarily by hepatic microsomal enzymes.Half life:parent drug:15-20 minutes.Time to peak serum concentration 1-2 hours.

Indications

Treatment of mild to moderate pain,inflammation,fever;prophylaxis for myocardial infarction and transient ischemic episodes;management of rheumatoid arthritis,rheumatoid fever,osteoarthritis and gout.

Contraindications

 Hypersensitivity to acetylsalicylic acid,hypoprothrombinemia,hemophilia and active peptic ulceration.

Precautions

Patients using enteric coated acetylsalicylic acid should be advised against ingesting antacids simultaneously,to avoid premature drug release.

Warnings

Acetylsalicylic acid should not be given to children,particularly under 12 years.

Side effects

Hypersensitivity,asthma,urate kidney stones,chronic gastro-intestinal blood loss,tinnitus,nausea and vomiting.

Pregnancy and lactation

Pregnancy risk factor D.

Dosage

For analgesic,antipyretic and anti-inflammatory actions:300-900 mg repeatd three to four times daily according to clinical needs.in acute rheumatic disorders 4-8 g daily,taken in divide doses.

Brands

Tabs.Disprin CV 100 mg,Tabs.Doloprin 75 mg,Tabs.Loprin 75 mg,Tabs.Ascard 75 mg.