L-Ornithine L-Aspartate

L-Ornithine L-Aspartate

Class:Cholagogues and hepatic

Mechanism of action

Ornithine is a initial substance which starts the detoxification cycle or urea cycle,by activating the urea cycle enzymes,carbamyl tranferase and synthetase.which converts toxic ammonia into toxic urea helps the disesed liver to perform normal functions smoothly.Thus promotes detoxification means,lower elevated level of ammonia in blood (hyperammonemia) and improved the subjective symptoms of nausea and vomiting.Aspartate an essential component of citric acid cycle,which liberates energy(ATP) helps registration of damaged cells.Thus restore normal metabolic function of liver improves the general symptoms of weakness.In addition aspartate is itself an excitatory neaurotransmitter and helps in maintaining the glutamate concentration in the brain.

Indications

Jaundice,acute hepatitis,adjuvant therapy with the tuberculostatic and cytotoxic drugs,post hepatitis syndrome,fatty liver with hyperammonia,cirrhosis,hepatic encephalopathy,hepatic pre-coma and coma.

Contraindications

None

Precautions

In patients with severe renal insufficiency,blood urea and serum creatinine must be monitored regularly,serum creatinine value exceeding 3 gm/ml is regarded as a reference value.

Side effects

Side effects of l-ornithine l-aspartate are not known so far.

Pregnancy and lactation

No data available

Drug interaction

No data available

Dosage

L-Ornithine L-Aspartate as a supportive therapy during mild to moderate liver disease:Adults:2 teaspoonful twice a day.Children:1 teaspoonful twice a day.Children:no clinical data is available for use below the age of 8 year.Infusion:Adults:in acute hepatitis:1-2 ampoule a day.In chronic hepatitis and hepatic cirrhosis:2-4 ampoula a day.In hepatic pre-coma:upto 8 ampoules within 24 hours.Infusion can safely be mixed with conventional infusion vehicles.Adults:1 sachet of l-ornithine l-aspartate granules fully dissolved in half a glass of water or juice,once or twice a dayCchildren:not recommended below the age of 8 years.

Brands

Syp.Hepa-merz,Inj.Levijon 500mg.