Protamine sulfate
Class:Antidote
Mechanism of action
Combines with
strongly acidic heparin to form a stable complex(salt) neutralizing the
anticoagulant activity of both drugs.
Pharmacokinetics
Onset of effect: IV
injection:heparin neutralization occurs within 5 minutes.
Indications
Heparin overdosage;neutralize
heparin during surgery or dialysis procedures.
Dosage
Protamine dosage is
determined by the dosage of heparin;1 mg of protamine neutralizes 90 USP units
of heparin(lung) and 115 USP units of heparin(intestinal);maximum dose 50 mg.Time
elapsed:immediate:1-1.5 mg protamine to neutralize 100 units of heparin.Time
elapsed:30-60 minutes:0.5-0.75mg protamine to neutralize 100 units of
heparin.Time elapsed:>2 hours:0.25-0.375mg protamine to neutralize 100 units
of heparin.
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