Domperidone

Domperidone

Class:Antiemetic and antinauseant

Mechanism of action

Domperidone is dopamine D2 receptor antagonist.within the gastrointestinal tract activation of dopamine receptor inhibit cholinergic smooth muscle stimulation,so these agents increase esophageal peristaltic amplitude,increase lower esophageal sphincter pressure,and enhance gastric emptying.

Pharmacokinetics

Domperidone is rapidly absorbed after oral administration,with peak plasma concentration at approximately 1 hours.

Indication

The dyspeptic symptom complex that is often associated with delayed gastric emptying,gastroesophageal reflux and esophagitis.epigastric sense of fullness,feeling of abdominal distension;upper abdominal pain;bloating,eructation,flatulence,nausea and vomiting.heartburn with or without regurgitation of gastric contents in the mouth.

Contraindications

Domperidone should not be used whenever stimulation of gastric motility might be dangerous.e.g,in the presence of gastrointestinal hemorrhage,mechanical obstruction or perforation.it is also contraindicated in patient with prolactin releasing pituitary tumour (prolactinoma).

Side effects

Transient intestinal cramps,extrapyramidal phenomena,galactorrhea and gynaecomastia,rash and urticaria.

Pregnancy and lactation

Nursing is not recommended for mothers,who are taking domperidone.

Drug interaction

Concomitant administration of anticholinergic drugs may antagonize the antidyspeptic effect of domperidone.antacid and antisecretory agents should not be given simultaneously with domperidone tablet and suspension as they lower its oral bioavailability.

Dosage

Chronic dyspepsia(mainly oral administration).adults:10 mg(1 tablet or 10 ml) 3 times daily,15-30 minutes before meals.Children:oral suspension 2.5 ml per 10 kg body weight ,3 times daily before meals.

Brands

Tabe.Domel 10mg,Tabe.Motillium 10 mg,Tabe.Stomeze 10 mg