Tretinoin
Class:Cytostatics,Anti-acne preparation
Mechanism of action
Keratinocytes in the sebaceous follicle become less adherent which allows
for easy removal;inhibits microcomedo formation and eliminates lesions already
present.
Pharmacokinetics
Absorption:Topical:minimum absorption occur.Metabolism:of the small
amount absorbed,metabolism occur in the liver.elimination in the bile and
urine.
Indications
Topical:acne vulgaris.oral:with anthracycline based chemotherapy in acute
promyelocytic leukemia.
Contraindications
Acute eczema,rosacea and acute inflammation of the skin.
Precautions
Contact of tretinoin with eyes,anterior naris and mucosa should be
avoided;otherwise thorough rinsing with water is recommended.
Pregnancy and
lactation
Should be avoided in pregnancy
Drug interaction
Special caution is indicated in case of simultaneous treatment with other
preparations,especially desquamative agents.if the patients was treated with
such an agent prior to the tretinoin therapy,it is recommended that the skin be
allowed to recover.
Dosage
Cream shall be applied once or twice daily for minimum 8 weeks.Oral:adults
and children:45mg/square meter daily in two divided doses with a meal.contnue
treatment until complete remission or up to maximum 90 days.
Cream.Retin-A,cream.Tretinex,Caps.Vesanoid.
