Tranexamic Acid

Tranexamic Acid

Class:Antihaemorrhagics/Antihaemophilic

Mechanism of action

Antiplasminic binds strongly with the lysine-bonding site(LBS),the site of fibrin affinity of plasmin and plasminogen,and inhibits the bonding of plasmin and plasminogen to fibrin.Therefore,the degradation of fibrin by plasmin is strongly inhibited.In the presence of antiplasmins,such as u2-macro globulin,in the plasma,the antifibrinolytic action of tranexamic acid is even further strenghthened.In case of ordinary haemorrhages,Tranexamic acid appear to cause hematosis by suppressing this fibrin degradation.

Pharmacokinetics

The concentrations in the blood,when 250mg and 500mg of tranexamic acid were administered orally to healthy adults,reached peak values 3.9 ug/ml(250mg administration) and 6.0 ug/ml (500mg administration) 2-3 hours after administration.The biological half lives was 3.1 hours and 3.3 hours,respectively.When 500mg of tranexamic acid were administered orally to healthy adults,the rate of excretion in the urine was about 30-52% by 24 hours after administration.

Indications

Leukemia,hypoplastic anemia,purpura or abnormal hemorrhages during or after operation.pulmonary,nasal,genital or renal hemorrhages,eczema or similar diseases,urticaria,drug rash or toxic exanthema.Tonsillitis,pharyngolaryngitis,pain in the oral cavity or mucosal aphtha in cases of stomatitis.

Side effects

Hypersensitivity,anorexia,nausea,vomiting,diarrhea,constipation,itching,exanthema,drowsiness.

Pragnancy and lactation

Pregnancy risk factor B.

Drug interactions

Since there is a possibility of thrombus formation tendencies due to concomitant administration with large doses of hemostatic organ preparation or hemocoagulate,is careful when administering concomitantly.

Dosage

Adults:The dosage of tranexamic acid is 750 to 2000mg/day of tranexamic acid is usually administered three to four times daily.The dosage should be adjusted according to the age of patients and severity of symptoms.

Brands

Caps.Maxna 250,500mg,Caps.Transamin 250,500mg,Inj.Utramax 250,500mg.