Orlistat
Class:Lipase inhibitor
Mechanism of action
Orlistat is a potent,specific
and reversible long acting inhibitor of gastrointestinal lipases.It exert its
therapeutic activity in the lumen of the stomach and small intestine by forming
covalent bond with the serine residue of the active site of gastric and
pancreatic lipases.The inactivated enzyme is thus unable to hydrolyse dietary
fat,in the form of triglycerides,into absorbable free fatty acids and
monoglycerides.As undigested triglycerides are not absorbed.
Indications
Obese patients or
severly overweight patients in conjunction with a mildly hypocaloric diet.
Contraindications
Chronic malabsorption
syndrome or cholestasis,hypersensitivity to orlistat or any component.
Side effects
Headache,dizziness,sleep
disorder,anxiety,dry skin,rash,oily spotting,fatty/oily stool.
Pregnancy
Pregnancy risk factor
B.
Drug interaction
Vitamin K absorption
may be decreased when taken with orlistat.
Dosage
One capsule of 120mg
during or upto one hour after the meal.
Brands
Tabs.Orlis
120mg,Tabs.Orslim 120mg.
